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Medicine is best for depression

SSRIs are considered first-choice medications for treating depression. These medications are believed to work by raising the amount of serotonin — a hormone that helps regulate mood — in the brain.
... 1. SSRIs
Citalopram (Celexa)
Escitalopram (Lexapro)
Fluoxetine (Prozac)
Paroxetine (Paxil)
Sertraline (Zoloft)

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SSRIs are the most widely prescribed type of antidepressants. They're usually preferred over other antidepressants, as they cause fewer side effects. An overdose is also less likely to be serious. Fluoxetine is probably the best known SSRI (sold under the brand name Prozac).

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Three of the more common methods used in depression treatment include cognitive behavioral therapy, interpersonal therapy, and psychodynamic therapy.
Paroxetine is known as a selective serotonin reuptake inhibitor (SSRI). This medication may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living. It may decrease fear, anxiety, unwanted thoughts, and the number of panic attacks.

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TREATMENT FOR MAJOR DEPRESSION For the initial treatment of major depression, we suggest a combination of antidepressant medication and psychotherapy. Well-designed studies have shown that combination treatment is more effective than either treatment on its own.
It's not unusual for antidepressants to make you feel drowsy. And among the different SSRIs, paroxetine seems to cause the most drowsiness. But this usually goes away after a few weeks of taking the medication.

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